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ZOMETA (zoledronic acid) Injection is an infused therapy and a member of the class of medicines called bisphosphonates. ZOMETA works by slowing the bone destroying activity that occurs with bone metastases. It also works by fighting the abnormal cells that cause bone to wear away (osteolytic lesion). Bone metastases wear away portions of bone leaving small holes called osteolytic bone lesions. This wearing away process causes eroded bone to appear as circular punched out areas. It leaves bones weak and fragile. Slowing the abnormal buildup of unstable bone (osteoblastic lesion) Bone metastases can also cause abnormal bone formation. Areas of new bone form but they are weak and unstable and can break easily or collapse. These areas are called osteoblastic bone lesions.

ZOMETA reduces the risk of bone complications such as bone fracture hypercalcemia of malignancy and spinal cord compression. ZOMETA helps restore the normal process of bone remodeling thus reducing the chance of bone complications. Even patients who have already had complications such as bone fracture radiation or bone surgery can be helped by treatment with ZOMETA.